Location:Austin, TX, USAEmployment Type:Full Time

Company Description:

Molecular Templates is a clinical stage biopharmaceutical company focused on the discovery and development of differentiated, targeted, biologic therapeutics for cancer. We believe our proprietary biologic drug platform technology, referred to as engineered toxin bodies, or ETBs, provides a differentiated mechanism of action that may address some of the limitations associated with currently available cancer therapeutics. ETBs utilize a genetically engineered form of Shiga-like Toxin A subunit, or SLTA, a ribosome inactivating bacterial protein, that can be targeted to specifically destroy cancer cells. Additional information about Molecular Templates can be obtained at www.mtem.com.


Position Overview:

Molecular Templates is seeking an experienced and highly-motivated professional to support downstream process development. The Associate Scientist  will be responsible for working with fellow team members to develop robust, efficient and scalable methods for protein purification/manufacture. This position will perform functions related to downstream process development of recombinant biologics, including experimentation involving protein purification, cell lysis, clarification, chromatography, ultrafiltration, diafiltration and filling.  Additional activities will include solution preparation, equipment maintenance and calibration, data management, report authoring, and review of manufacturing processes. This position will also aid in identifying continuous process improvement areas. This will require excellent technical, analytical and organizational skills, along with adherence to written and verbal instructions and accurate and timely completion of experimental records.


Job Responsibilities will include:

  • Perform protein purification experiments and analysis for downstream process development. This includes, but not limited to: buffer and solution preparation, cell lysis, various filtration methods, centrifugation, chromatography, column packing and packed bed qualification, various sterilization methods, vialing and labeling, process data recording and trending.
  • Conduct limited characterization of protein products, impurities, and protein purification using common laboratory techniques.
  • Maintain detailed experimental records.  Complete required documentation in an accurate and timely manner, adhering to written procedures and regulatory requirements.
  • Review and revise established protocols and SOPs related to drug development, such as process development and optimization techniques. This may also include developing and optimizing assays, conducting limited literature search of research study protocols and reports, regulatory documents, and other potential resources.
  • Conduct general laboratory duties, including washing glassware, ordering supplies, and maintaining inventory e.g. buffer and basic laboratory equipment
  • Assist with non-complex projects, such as laboratory sanitization and organization or implementation of new instrumentation, as needed
  • Pre-clinical manufacture (lab scale) of biologics for animal studies.
  • Support downstream manufacturing investigations through scale-down studies and experimental investigations.
  • Author technical reports for internal review.



  • Bachelor's degree in Life Sciences or equivalent
  • Minimum of one 1 year relevant experience in laboratory setting conducting or supporting protein purification methods
  • Demonstrated experience in downstream processing activities/protein purification, required
  • Experience in biopharmaceutical industry, preferred
  • Experience with HPLC, preferred
  • Experience with statistical, multivariate analysis and JMP software, preferred
  • Excellent written and verbal communication skills
  • Excellent computer skills with knowledge of spreadsheet and word processing
  • Excellent problem-solving and analytical skills applied to investigations
  • Excellent organizational, time management and multi-tasking skills
  • Ability to follow written and verbal instruction and work under supervision
  • Ability to work in a fast-paced, team environment
  • Ability to lift 30 lbs. and must be able to stand, crouch, sit, bend, or stretch for extended periods of time
  • Must possess flexibility to work varying schedules to support operations, such as occasional 12-hour shift or night shift


Reporting Structure:

This position currently has no supervisory responsibilities. This position reports to Manager, Downstream Development.

Molecular Templates, Inc. is an Equal Opportunity Employer and offers competitive salaries and benefits.

Molecular Templates Inc
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